In 1841, this parish was established for the inhabitants of Faubourg Tremé. The joint beneficence of Bishop Antoine Blanc and the Ursuline nuns made possible acquisition of property and erection of the church. Until 1925, the buildings of the Collége d’Orléans and the motherhouse of the Sisters of Mount Carmel stood in this square. In 1842, the Sisters of the Holy Family began their apostolate for Blacks within this parish under the guidance of Abbé Étienne Rousselon, founding pastor. Alexandre P. Tureaud, attorney and noted Louisiana civil rights leader, was baptized here April 2, 1899. In 1963, priests of the Society of the Divine Word began serving the parish.