This brick façade was once part of the first Mount Sinai Hospital, an institution founded in 1922 to provide medical services particularly for the city's many Jewish immigrants. Since existing hospitals did not offer such services as Yiddish-speaking staff or kosher food, the Ezras Noshem Society, a "ladies' aid" organization, held a successful fundraising campaign and opened the Jewish Maternity and Convalescent Hospital on this site. Reorganized and renamed Mount Sinai Hospital in 1923, the small facility also welcomed Jewish doctors and medical interns - often excluded from other hospitals.
In 1934, architects Benjamin Kaminker and Edward Richmond designed this façade as an addition to the hospital. In 1953, Mount Sinai moved to a new site on University Avenue. The façade, the only remaining portion of the old hospital building, was incorporated into a residential and commercial development completed in 2009.